According to a survey from the National Health Insurance Research Database (NHIRD), Jia-Wei-Xiao-Yao-San (JWXYS) is the most\npopular Chinese medicine for cancer patients in Taiwan. 5-Fluorouracil (5-FU) is a general anticancer drug for the chemotherapy.\nTo investigate the herb-drug interaction of JWXYS on pharmacokinetics of 5-FU, a micro dialysis technique coupled with a high performance\nliquid chromatography system was used to monitor 5-FU in rat blood and brain. Rats were divided into four parallel\ngroups, one of which was treated with 5-FU (100mg/kg, i.v.) alone and the remaining three groups were pretreated with a different\ndose ofJWXYS (600, 1200, or 2400mg/kg/day for 5 consecutive days) followed by a combinationwith 5-FU.This study demonstrates\nthat 5-FU with JWXYS (600mg/kg/day or 1200mg/kg/day) has no significant effect on the pharmacokinetics of 5-FU in the blood\nand brain.However,JWXYS (2400mg/kg/day) coadministered with 5-FU extends the elimination half-life and increases the volume\nof distribution of 5-FU in the blood.The elimination half-life of 5-FU in the brain for the pretreatment group with 2400mg/kg/day\nof JWXYS is significantly longer than that for the group treated with 5-FU alone and also reduces the clearance.This study provides\npractical dosage information for clinical practice and proves the safety of 5-FU coadministered with JWXYS.
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